Bioanalytical Core Laboratory

The objective of the core facility is to provide bioanalytical technology services and help investigators to achieve the research objectives by using biochemical testing. The Pediatric Clinical Research Center's Bioanalytical Core Laboratory is located within the clinical laboratory on the 2nd floor Main Hospital Building. Services of the Bioanalytical core lab are available to investigators at CNMC, as well as to outside clients, on a fee-for-service basis. The laboratory provides sophisticated biochemical assays and is dedicated to the development, validation and application of bioanalytical methods in support of clinical, pharmacokinetic and pharmacogenetic studies. Analysis of metabolites can be accomplished from a few drops of blood or urine blotted on paper. New assays can be applied or developed using the technology or equipment listed below.

• Method development for established and experimental drugs or other analysis of interest.
• Method validation
• Sample analysis from clinical studies
• Confirmation of mass and/or purity of products resulting from synthesis or in-vitro metabolism studies
• Chiral assays
• Separation and collection of chiral enantiomers
• Immunoassays
• Use of HPLC as sample clean-up for immuno-assays

The laboratory maintains the equipment listed below:

• 4 GC-mass spectrometers
• 1 HPLC mass spectrometer
• 2 TANDEM mass spectrometer
• automated amino acid analyzer
• automated immunoassay analyzer

Staff is available to discuss the aims of your project and how the bioanalytical core lab can help you to achieve your research goals. Larger scope projects may need to be set up as a collaborative effort and should be discussed with the Center Director. If you are interested in using the core facilities, please call to set up a meeting with the core laboratory Director, Steven J. Soldin, Ph.D. at Tel. 202 884-2096 or e-mail: ssoldin@cnmc.org.